# Conservation of known vertebrate cyclooxygenase functional domains and residues # Antarctic invertebrates # PI: K. Halanych (Auburn U) # version: 2016-12-27 # NOTE: These data were publishedl (201ble 3 of Havird et a0072015) J Mol Evol. DOI 10.1 AA_Re-015-9670-3 # AA_Residue: presence (+); absence (-) ========================= Domain_or_residue AA_Residue Amphimdeon Insecta Brachiopoda Nemertea Annelida Mollusca Sipuncula Myriapoda Crustacea Cephalochordata ------------------------- Cyclooxygenase = active residues Y-385 - - + + + + +/- - + + Cyclooxygenase = active residues H-388 - +/- + + + + +/- - + + Cyclooxygenase = active residues S-530 - - unknown + + + - + +/- + Peroxidase active residues Q-203 - +/- unknown + + + - + + + Peroxidase active residues H-207 - - unknown + + + +/- + + + Substrate-binding site R-120 - - unknown + + + - + + +/- Endoplasmic reticulum (ER) retention signal 596-599 - - unknown + + + - + - + N terminal signal peptide 1-24 - +/- unknown + + + + + + +/- Membrane-binding domain 71-115 - +/- unknown + + + + + + + N-glycosylation residues N-68 - +/- unknown + +/- +/- + - +/- +/- N-glycosylation residues N-104 - +/- unknown + + +/- + + + + N-glycosylation residues N-144 - +/- unknown + + + + + + - N-glycosylation residues N-410 - +/- + - +/- - + - - + N-glycosylation residues N-593 - - unknown - +/- +/- +/- - +/- +/- Dimerization domains 33-70 - +/- unknown + + + + + + + Dimerization domains 124-142 - +/- unknown + + + - + + + Haem-binding domain 312-316 + +/- unknown + + + + + + + Haem-binding domain 305-314 - +/- unknown + + + + + + + N-terminal insertions 23-32 - +/- unknown + + +/- + + + +/- C-terminal insertions 573-588 - - unknown - - - - - +/- +/- Vert. inhibitor target residues R-513 - - unknown + + +/- +/- - - - Vert. inhibitor target residues V-523 + - unknown + - +/- - + + +/-